What is CAR-T cell therapy?

In recent years, a new treatment for cancer has been adopted: immunotherapy. Immunotherapy is based on strengthening the patient’s own immune system to attack tumors. A particularly successful and novel type of immunotherapy is CAR-T cell therapy. CAR-T therapy involves separating out the T cells from a patient’s blood and engineering them to produce chimeric antigen receptors (CARs). CARs allow T cells to identify and attach to antigens on tumor cells, so when they’re reinjected into the patient’s body, the modified T cells can identify and kill cancer cells that have the target antigen on their surfaces. As with any cancer treatment, the side effects of CAR-T cell therapy must be considered. One of the most common side effects of CAR T-cell therapy is cytokine release syndrome (CRS) where T cells release cytokines (to help stimulate the immune system) too rapidly, causing dangerous fevers and blood pressure fluctuations.

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