Manini Penikalapati

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DNA methylation occurs when a methyl group (CH3) is added to DNA, most often the 5-carbon of the cytosine ring. These methyl groups inhibit transcription because the shape of the nucleotide is changed, which modifies the function of the genes and affects expression. DNA ...Learn More


Next generation sequencing is a broad term used to describe modern sequencing technologies. NGS allows for much more efficient DNA and RNA sequencing (quick and cheap) than Sanger sequencing. Sanger sequencing refers to the old method for determining the nucleotide sequence of ...Learn More


Single-base editing is a new gene-editing technique that converts one base into another. Old techniques have only been able to take advantage of complementary base pairing and change a G-C pair into an A-T pair, but this new method changes adenine into inosine, which reads as ...Learn More


There is a huge demand for successful gene-editing technology to make gene therapy the future of medicine. The possibility of curing a whole host of nasty diseases by correcting a single faulty gene is one so many scientists are working towards. There are four main gene-editing ...Learn More


Nucleic acid detection and analysis is accomplished using recombinant DNA technology to isolate individual genes and characterize them based on their proteins. This technology can be carried out through many different protocols depending on the specifics of the nucleic acid(s) ...Learn More



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