Webinar: Live Imaging of the Extracellular Matrix With a Glycan-Binding Fluorophore

June 9th, 2026 10:00 AM EDT

Session Description

Visualizing the extracellular matrix (ECM) in real-time has long been a challenge. Dr. Kayvon Pedra’s group has developed a novel, cell-impermeant fluorophore that red-shifts and activates upon binding glycans. This allows for seamless, wash-free imaging of glycosylated ECM architecture—from in vitro models to in vivo mouse tumors—providing a powerful new tool for live fluorescence microscopy.

Highlights of the presentation

lA cell-impermeable small molecule fluorophore turns on and red-shifts upon binding glycosylated biomolecules.

lApplication of the dye to live biological samples enables wash-free visualization of extracellular matrix structure.

lObservations demonstrate no toxicity, a broad substrate profile, deep tissue penetration, and negligible photobleaching in a variety of model organisms.

Free registration here.

Webinar Speaker

Dr. Kayvon Pedram

Group Leader at HHMI's Janelia Research Campus

Kayvon is a Group Leader at HHMI's Janelia Research Campus near Washington, D.C. He received his bachelor's degree in 2015 from MIT working with Prof. Alice Ting and his Ph.D. in 2021 from Stanford working with Prof. Carolyn Bertozzi. The Pedram Lab, established in 2021, aims to discover principles by which extracellular assemblies govern mammalian biology across spatial scales, develop therapies that take advantage of the unique and underexplored properties of extracellular biomolecules, and widely distribute methods that will allow others to join those long-term efforts. For more information, see https://pedramlab.com.