Delivering neoantigen peptides with nanoparticles

In this episode, Dr. Geoffrey Lynn talks about the development of a polymer-based antigen delivery technology- SNAP, or self-assembling nanoparticles, displaying a patient’s own neoantigens to induce a CD8 T-cell response and tumor regression in animal models. The work was published on Nature Biotechnology on Jan 13th, 2020, Peptide–TLR-7/8a conjugate vaccines chemically programmed for nanoparticle self-assembly enhance CD8 T-cell immunity to tumor antigens.