In Parkinson's disease, the death of substantia nigra dopamine-producing neurons unleashes a sequel of progressive motor and non-motor dysfunctions. There is no cure for this neurodegenerative disease which is only second to Alzheimer's disease in prevalence among the elderly. ...Learn More

Spinal cord injuries affect ~17,810 individuals each year in the USA, with no cure yet in sight. Based on the National Spinal Cord Injury Statistical Center, spinal cord injuries often result from vehicular accidents and falls, accounting for 38.6% and 32.2% of injuries since ...Learn More

Organoids, or mini-organs, may be grown from various cell types, including embryonic stem cells, induced pluripotent stem cells, or even adult stem cells. Unlike the classical monolayer cell cultures, organoids are developed to replicate the 3D cellular composition and ...Learn More

The CRISPR/Cas9 gene-editing tool kit has facilitated gene knockins above any other strategy developed to date. Still, improving efficiency and specificity remain challenging aspects of CRISPR/Cas9 directed gene insertions. In a continued effort to enhance knockin efficiency, ...Learn More

CRISPR news took center stage last year, with the 2020 Nobel Prize in Chemistry awarded to pioneers in the field, Dr. Jennifer A. Doudna and Dr. Emmanuelle Charpentier. The Nobel Prize win was the icing on the cake. Overall advances based on CRISPR editing tools were impressive in ...Learn More