Cell-specific delivery of genes is an attractive and desirable strategy for inherited rare diseases for its potential curative outcomes. Thus, adeno-associated virus (AAV) vectors have been increasingly used as delivery vehicles for developing gene therapies. Although AAVs have ...Learn More

Inherited Retinal Diseases (IRDs) are a genetically heterogeneous group of conditions often leading to progressive vision loss and affecting different retinal cell types (Cremers et al. 2018, Toualbi et al. 2021). A gene therapy approach to improve vision relies on the delivery of ...Learn More

The CRISPR/Cas13 family consists of four nuclease subtypes, Cas 13a-d. Unlike CRISPR/Cas9 and CRISPR/Cas12, which target DNA, CRISPR/Cas13 is guided by RNA to target specific RNA sequences for degradation. In addition to targeted RNA degradation, Cas13 leads to “collateral RNA ...Learn More

cPass™ Neutralizing Antibody Detection for COVID-19 Post Vaccination Monitoring

An Antibody Drug Conjugate (ADC) is a vector-based chemotherapy that relies on the use of a monoclonal antibody (mAb) linked to an anticancer cytotoxic drug (DeCarvalho et al. 1964). Unlike conventional chemotherapy methods, ADCs can selectively target diseased cells, minimizing ...Learn More