The CRISPR-Cas9 system has been adopted as a tool to manipulate the genomes of multiple living organisms, accelerating the pace of fundamental research and enabling clinical and agricultural breakthroughs. Besides, a newer type of genome editing approaches, named base-editor (BE) ...Learn More

After two-month fierce voting competition, 2020 MolecularCloud Distinguished Research Awards will be given to:Dr. Zheng-Li Shi and her team at the Wuhan Institute of Virology;Dr. David Veesler and his team at the University of Washington;teams of Dr. Bert Schepens and Dr. Xavier ...Learn More

The CRISPR–Cas9 system is able to recognize target sequences based purely on nucleotide sequences, and it has been adapted for genome editing in both eukaryotes and prokaryotes. Recently, a new family of CRISPR-based genome-editing methods, named base-editor techniques, was ...Learn More

Controlling the copy number of gene expression cassettes is an important strategy to engineer bacterial cells into high-efficiency biocatalysts. Current strategies mostly use plasmid vectors, but multicopy plasmids are often genetically unstable, and their copy numbers cannot be ...Learn More

Rapid growth of the human population accompanied with urbanization and climate change is creating an environment conducive to the emergence of previously uncommon arboviruses, such as Zika virus (ZIKV). ZIKV poses a substantial public health concern due to the congenital ...Learn More