Controlling the copy number of gene expression cassettes is an important strategy to engineer bacterial cells into high-efficiency biocatalysts. Current strategies mostly use plasmid vectors, but multicopy plasmids are often genetically unstable, and their copy numbers cannot be ...Learn More

Rapid growth of the human population accompanied with urbanization and climate change is creating an environment conducive to the emergence of previously uncommon arboviruses, such as Zika virus (ZIKV). ZIKV poses a substantial public health concern due to the congenital ...Learn More

SpCas9-NG self-targets the sgRNA sequence in plant genome editingDr. Pengcheng Wei’s team published the paper “SpCas9-NG self-targets the sgRNA sequence in plant genome editing ” at Nature Plants in 24 February 2020. The plasmid pHUC411-gcccc and pHUC411NG-gcccc of this ...Learn More

Can molecular nanomachines solve the problem of multi-drug-resistant pathogens?Recently, Dr. Jeffrey Cirillo's team published the paper "Molecular Nanomachines Disrupt Bacterial Cell Wall, Increasing Sensitivity of Extensively Drug-Resistant Klebsiella pneumoniae to Meropenem." in ...Learn More

A monatomic gold reactor constructed in a conical biological nanopore Dr. Shuo Huang's team published the paper "Giant single molecule chemistry events observed from a tetrachloroaurate(III) embedded Mycobacterium smegmatis porin A nanopore" at Nature Communications in 11 Dec ...Learn More