Zhengli Shi

Dr. Zhengli SHI graduated from Wuhan University in 1987 and pursued her graduate studies in Wuhan Institute of Virology, Chinese Academy of Sciences (1987-1990), and Montpellier University II, France (1996-2000). She has been working on discovery and characterization of novel viruses from bats and other wildlife. She carried out systemic studies on epidemiology, genetic evolution, interspecies infection mechanism and pathogenesis of bat viruses. The accomplishments of Dr. Shi include 1) identify the pathogen of COVID-19 and its probable bat origin; 2) identify the pathogen causing swine acute diarrhoea syndrome and its bat origin; 3) identify a gene pool of SARS-related coronaviruses; 4) discover a large number of novel bat viruses, including filoviruses, adenoviruses, reoviruses, circovirus, etc. Owing to her original scientific findings and contributions to bat virus research field, Dr. Shi won the second prize of Natural Science Award of China in 2018 and was elected as fellowship of American Academy of Microbiology in 2019. She has provided editorial service to Virology, Virol J and has served since 2017 as Editor-in-Chief for Virologica Sinica.

Lab Information

CAS Key Laboratory of Special Pathogens, Wuhan Institute of Virology, Chinese Academy of Sciences

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SARS-CoV 1 Epidemiology 1 Viruse 1 Interspecies Mechanism 1 Bat 1 Rodent 1


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Hello everyone! I have successfully joined Cloud Scientist program! I‘m Zhengli Shi, a Principal Investigator of CAS Key Laboratory of Special Pathogens, Wuhan Institute of Virology, Chinese Academy of Sciences. I have been working on discovery and characterization of novel ...Learn More

  1. Zhou, P., Yang, X. L., Wang, X. G., Hu, B., Zhang, L., Zhang, W., ... & Chen, H. D. (2020). A pneumonia outbreak associated with a new coronavirus of probable bat origin. nature, 579(7798), 270-273.

  2. Zhang, Wei, Rong-Hui Du, Bei Li, Xiao-Shuang Zheng, Xing-Lou Yang, Ben Hu, Yan-Yi Wang et al. "Molecular and serological investigation of 2019-nCoV infected patients: implication of multiple shedding routes." Emerging microbes & infections 9, no. 1 (2020): 386-389.

  3. Hu B, Zeng LP, Yang XL, Ge XY, Zhang W, Li B, Xie JZ, Shen XR, Zhang YZ, Wang N, Luo DS, Zheng XS, Wang MN, Daszak P, Wang LF, Cui J, Shi ZL. (2017). Discovery of a rich gene pool of bat SARS-related coronaviruses provides new insights into the origin of SARS coronavirus. PLoS Pathogens. 13(11):e1006698.

  4. Zeng LP, Ge XY, Peng C, Tai W, Jiang S, Du L, Shi ZL. (2017). Cross-neutralization of SARS coronavirus-specific antibodies against bat SARS-like coronaviruses. Sci China Life Sci. doi: 10.1007/s11427-017-9189-3.

  5. Zhang Q, Zeng LP, Zhou P, Irving AT, Li S, Shi ZL, Wang LF. (2017). IFNAR2-dependent gene expression profile induced by IFN-α in Pteropus alecto bat cells and impact of IFNAR2 knockout on virus infection. PLoS One. 12(8):e0182866.

  6. Wang B, Cai CL, Li B, Zhang W, Zhu Y, Chen WH, Zhuo F, Shi ZL, Yang XL. (2017). Detection and characterization of three zoonotic viruses in wild rodents and shrews from Shenzhen city, China. Virol Sin. 32(4):290-297.

  7. Liang J, Yang XL, Li B, Liu Q, Zhang Q, Liu H, Kan HP, Wong KC, Chek SN, He X, Peng X, Shi ZL, Wu Y, Zhang L. (2017). Detection of diverse viruses in alimentary specimens of bats in Macau. Virol Sin. 32(3):226-234.

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