xueli zhang

Dr. Xueli Zhang received his doctoral degree in 2005 from Shanghai Jiao Tong University. From 2005 to 2007, he worked as a Post-doctoral at the Department of Microbiology and Cell Science, University of Florida. Dr. Zhang is currently a Principal Investigator and Professor at the Tianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences. Dr. Zhang’s research focuses on constructing microbial cell factories for production of bulk chemicals and plant-derived natural products through metabolic engineering and synthetic biology. Research interests include: (1) Identification of new enzymes for natural products synthesis using metabolic engineering platforms, followed by enzyme optimization. (2) Design and construction of synthetic pathways, followed by pathway optimization through coordinated gene expression, cofactor engineering and metabolic evolution. (3) Optimization of cell physiology through adaptive evolution, followed by characterization of their genetic mechanisms. (4) Development of new genome editing methods.

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Tianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences

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Metabolic Engineering 0 Synthetic Biology 0 Genome Editing 0

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Hello everyone! I have successfully joined Cloud Scientist program! I’m Xueli Zhang, a Principal Investigator of the Tianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences. My research focuses on constructing microbial cell factories for production of bulk ...Learn More


  1. Zhao, D., Li, J., Li, S., Xin, X., Hu, M., Price, M. A., ... & Zhang, X. (2020). Publisher Correction: Glycosylase base editors enable C-to-A and C-to-G base changes. Nature biotechnology.

  2. Wu T, Li S, Ye L, Zhao D, Fan F, Li Q, Zhang B, Bi C*, Zhang X*. Engineering an Artificial Membrane Vesicle Trafficking System (AMVTS) for the Excretion of β-Carotene in Escherichia coli. ACS Synth Biol. 2019. 8(5):1037-1046.

  3. Dai Z, Liu Y, Sun Z, Wang D, Qu G, Ma X, Fan F, Zhang L, Li S, Zhang X*. Identification of a novel cytochrome P450 enzyme that catalyzes the C-2α hydroxylation of pentacyclic triterpenoids and its application in yeast cell factories. Metab Eng. 2019. 51:70-78

  4. Wu T, Ye L, Zhao D, Li S, Li Q, Bi C*, Zhang X*. Membrane engineering - A novel strategy to enhance the production and accumulation of β-carotene in Escherichia coli. Metab Eng. 2017, 43:85-91.

  5. Li Q, Fan F, Gao X, Yang C, Bi C, Tang J, Liu T, Zhang X*. Balanced activation of IspG and IspH to eliminate MEP intermediate accumulation and improve isoprenoids production in Escherichia coli. Metab Eng. 2017. 44:13-21

  6. Zhu X, Zhao D, Qiu H, Fan F, Man S, Bi C*, Zhang X*. The CRISPR/Cas9-facilitated multiplex pathway optimization (CFPO) technique and its application to improve the Escherichia coli xylose utilization pathway. Metab Eng. 2017. 43:37-45.


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