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Dr. Zuris discussed the rationale and approach for generating a new AsCas12a variant or AsCas12 ULTRA, how the newly developed variant compares in activity and specificity against other nucleases, and its application to T and NK cell gene editing.

During the construction of expression vectors, we usually add different tags to the vectors aim to simplify downstream detection and purification. Series of pcDNA3.1 vectors, as the widely used mammalian expression vectors, which can be added to many types of protein tags. The ...Learn More

In the field of pharmaceuticals and biotechnology studies, we generally use the plasmid vector to deliver the target genes into mammalian cells by transfection method in the laboratory. Based on the functions and usages, plasmid vectors are usually divided into cloning vectors and ...Learn More

The latest report reveals the mechanism of SARS-CoV-2 entering host cells is dependent on the cell receptor ACE2 and the serine protease TMPRSS2 to enter the cell. These results suggest the possible therapeutic targets and vaccine development for COVID-19! ...Learn More

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