As the lead PI of the Synaptopathies Initiative, Prof. Dimitri Kullmann and his lab’s research emphasizes on the fundamental mechanisms of synaptic transmission, together with the computational properties of small neuronal circuits, circuit excitability in epilepsy and other neurological disorders. One goal of the Kullmann lab is to reveal how the phenomena they studied at the cellular level, which encompass synaptic, extra-synaptic and non-synaptic signaling, LTPs, interact and regulate the excitability of small neuronal circuits. The lab has been incorporating diversiform approaches into experiments besides in vitro electrophysiology and pharmacology, including confocal and two-photon laser scanning microscopy, gene manipulation techniques like CRISPR-Cas9, and computational simulations which are utilized in their studies on hippocampal circuit. Prof. Kullmann is cooperating with a group of scientists to work on inherited neurological diseases caused by channelopathies, and epilepsy, while his lab has developed several promising strategies for gene therapy of focal epilepsy.
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Ion Channels 0 Synaptic Transmission 0 Neuronal Circuits 0 Epilepsy 0 Channelpathies 0
Hello everyone! I have successfully joined Cloud Scientist program！I‘m Dimitri Kullmann, a lead PI of the Synaptopathies Initiative. My lab’s research emphasizes on the fundamental mechanisms of synaptic transmission, together with the computational properties of small ...Learn More
Colasante G, Qiu Y, Massimino L, et al. In vivo CRISPRa decreases seizures and rescues cognitive deficits in a rodent model of epilepsy. Brain. 2020;143(3):891-905.
Bygrave AM, Kilonzo K, Kullmann DM, Bannerman DM, Kätzel D. Can N-Methyl-D-Aspartate Receptor Hypofunction in Schizophrenia Be Localized to an Individual Cell Type?. Front Psychiatry. 2019;10:835. Published 2019 Nov 21.
Thor MG, Vivekanandam V, Sampedro-Castañeda M, et al. Myotonia in a patient with a mutation in an S4 arginine residue associated with hypokalaemic periodic paralysis and a concomitant synonymous CLCN1 mutation. Sci Rep. 2019;9(1):17560.
Colasante G, Lignani G, Brusco S, et al. dCas9-Based Scn1a Gene Activation Restores Inhibitory Interneuron Excitability and Attenuates Seizures in Dravet Syndrome Mice. Mol Ther. 2020;28(1):235-253.
Snowball A, Chabrol E, Wykes RC, et al. Epilepsy Gene Therapy Using an Engineered Potassium Channel. J Neurosci. 2019;39(16):3159-3169.