In recent years, the landscape of drug discovery has evolved dramatically, leading to a significant shift towards targeted therapies. At the heart of this transformation lies a focus on kinases—enzymes that play crucial roles in various cellular processes, including metabolism, ...Learn More

G protein-coupled receptors (GPCRs) represent a vast and diverse family of membrane proteins that play a crucial role in various physiological processes. They are integral to the mechanism of action for a significant percentage of all current therapeutic agents. Consequently, GPCR ...Learn More

Epigenetics, the study of heritable changes in gene expression that do not involve alterations to the underlying DNA sequence, is revolutionizing the field of medicine. Epigenetic modifications can regulate gene activity, influencing various biological processes, including ...Learn More

In the realm of pharmaceutical research and development, understanding how compounds move across biological membranes is crucial. The Caco-2 permeability assay emerges as a pivotal technique for assessing the intestinal absorption of drug candidates, providing insights into their ...Learn More

Kupffer cells, the resident macrophages of the liver, play a critical role in maintaining hepatic homeostasis and responding to various physiological and pathological stimuli. Their unique position within the liver allows them to interact with numerous cell types and participate ...Learn More