By:DengYue International Business Division

For many patients, receiving a diagnosis is only the beginning of their treatment journey.

Particularly in the fields of cancer, rare diseases, and other complex conditions, patients may still face disease progression, recurrence, or limited treatment effectiveness even after undergoing surgery, chemotherapy, radiotherapy, or other standard treatments.

In the past, treatment options were often limited once standard therapies stopped working. However, with the rapid development of precision medicine, physicians are increasingly asking a new question:

Why do patients with the same disease respond so differently to the same treatment?

The answer often lies in the unique characteristics of each patient.

Genetic mutations, molecular profiles, disease subtypes, and prior treatment history can all influence treatment outcomes.

As a result, more international patients are turning to precision medicine evaluations to explore new treatment possibilities and receive personalized treatment recommendations rather than relying solely on a disease diagnosis.

Which Patients Are Most Likely to Benefit from a Precision Medicine Evaluation?

Precision medicine does not mean that every patient requires complex testing.

However, for certain patient groups, a precision medicine evaluation can play an important role in identifying additional treatment opportunities.

1. Patients with Advanced Cancer

For patients with advanced or metastatic cancer, standard treatment options have often already been exhausted through multiple lines of therapy.

Examples include:

● Lung cancer patients who develop resistance after targeted therapy

● Breast cancer patients experiencing disease recurrence

● Colorectal cancer patients with limited response to current treatments

● Gastric cancer patients with few remaining treatment options

In these situations, traditional pathology alone may no longer provide sufficient information for treatment planning.

Precision medicine evaluations can help physicians analyze:

For some patients, a new genetic finding may completely change the direction of treatment.

2. Patients with Recurrence or Treatment Resistance

Cancer treatment is not static.

Many patients initially respond well to therapy but later experience recurrence or treatment resistance as the disease evolves.

This does not necessarily mean that all treatment options have been exhausted.

In fact, the disease itself may have changed.

Examples include:

● The emergence of new driver mutations

● Tumor evolution over time

● Loss of effectiveness of previous therapeutic targets

● Changes in the tumor immune microenvironment

For this reason, many oncology specialists recommend re-evaluating patients through precision medicine after recurrence rather than simply repeating previous treatment strategies.

3. Patients with Rare or Difficult-to-Diagnose Diseases

For many rare disease patients, obtaining an accurate diagnosis can be more challenging than treatment itself.

Patients may experience:

● Years without a definitive diagnosis

● Multiple misdiagnoses

● Complex symptoms with slow progression

● Difficulty identifying the underlying cause of disease

Advances in genomic sequencing and molecular diagnostics have significantly improved diagnostic capabilities for rare diseases.

For patients with inherited metabolic disorders, neurological diseases, pediatric rare diseases, and certain autoimmune conditions, precision medicine evaluations can help uncover the underlying cause and guide future treatment and disease management.

4. Patients Seeking a Second Medical Opinion

Even after receiving a treatment recommendation, some patients may wish to explore additional options.

Common questions include:

● Are there alternative treatment approaches?

● Are there newer recommendations in international guidelines?

● Is there a more suitable treatment pathway for my condition?

● Am I eligible for a clinical trial?

Precision medicine evaluations focus not only on the disease itself but also on the unique characteristics of each patient.

As a result, they have become an increasingly valuable tool for patients seeking a second medical opinion.

What Opportunities Have Emerged from the Development of Precision Medicine Centers in China?

Over the past decade, China has made significant progress in precision medicine.

From genomic testing and molecular diagnostics to CAR-T therapy and innovative drug development, China has gradually established a comprehensive precision medicine ecosystem that spans diagnosis, evaluation, and treatment.

For international patients, this means greater access to medical resources and more potential treatment opportunities.

1. Advanced Genomic Testing and Molecular Diagnostic Capabilities

Precision medicine begins with precision diagnosis.

Today, many leading Chinese medical institutions offer a wide range of advanced diagnostic technologies.

These technologies help physicians better understand the disease and determine whether a patient may benefit from specific therapies.

2. Rapidly Maturing Precision Oncology Programs

In the past, precision medicine often focused primarily on testing.

Today, many precision medicine centers provide integrated care pathways that connect diagnostics directly with treatment planning.

Typical precision oncology workflow:

Pathological Diagnosis

↓

Genomic Testing

↓

Molecular Analysis

↓

Multidisciplinary Team (MDT) Evaluation

↓

Personalized Treatment Plan

Diagnostic reports are no longer simply laboratory results—they have become an important part of clinical decision-making.

3. Expanding Access to Innovative Therapies

China has experienced rapid growth in several cutting-edge therapeutic fields.

Examples include:

● CAR-T cell therapy

● Bispecific antibodies

● Antibody-drug conjugates (ADCs)

● Cancer immunotherapy

● Gene therapy

For some patients with advanced disease, precision medicine evaluations may help identify not only existing treatment options but also opportunities to access emerging therapies.

4. Growing Clinical Trial Opportunities

For patients with limited standard treatment options, clinical trials may represent an important alternative.

Precision medicine evaluations can help determine:

● Whether a patient meets eligibility criteria

● Whether specific molecular characteristics match trial requirements

● Whether participation in innovative drug studies may be appropriate

As a result, precision medicine has become an important bridge connecting patients to novel therapies and research opportunities.

How Does Dengyue Help International Patients Complete Precision Medicine Evaluations?

For many international patients, the biggest challenge is not the lack of medical resources but understanding how to access them effectively.

Medical records, translation, testing, specialist evaluations, and treatment recommendations all involve multiple steps.

Without proper coordination, patients may spend considerable time and effort navigating the process.

1. Medical Record Organization and Medical Translation

Every precision medicine evaluation begins with complete and accurate medical documentation.

Dengyue assists patients in organizing:

● Pathology reports

● Discharge summaries

● Genetic testing reports

● Medical imaging records

● Previous treatment history

We also provide professional medical translation services to help Chinese specialists efficiently understand each patient's condition.

2. Precision Medicine Resource Matching

Different diseases require different evaluation pathways.

For example:

By matching patients with disease-specific resources, Dengyue helps ensure that each patient enters the most appropriate evaluation pathway.

3. Specialist Pre-Evaluation and Treatment Direction Analysis

Before beginning treatment, patients can often undergo an initial case review.

Specialists evaluate:

● Existing medical records

● Test results

● Treatment history

● Disease stage

This helps patients understand:

✓ Their current disease status

✓ Whether additional testing may be necessary

✓ Potential treatment options

✓ Eligibility for innovative therapies

This process allows patients to gain a clearer understanding of their treatment possibilities before making major medical decisions.

4. One-Stop International Patient Support

Cross-border healthcare involves far more than medical treatment alone.

Dengyue provides comprehensive support services, including:

Our goal is to help international patients navigate the precision medicine evaluation process more efficiently and confidently.

Conclusion

The goal of precision medicine is not to find the most advanced treatment, but to identify the treatment that is most appropriate for a specific patient.

For patients with advanced cancer, treatment resistance, rare diseases, or those seeking a second medical opinion, precision medicine evaluations may uncover additional therapeutic opportunities that would otherwise remain undiscovered.

As China's precision medicine ecosystem continues to evolve, international patients are gaining access to increasingly sophisticated diagnostic resources, personalized treatment options, and innovative therapies.

With proper medical record preparation, professional translation, and scientifically guided evaluation, patients can take an important first step toward a more individualized treatment pathway. Dengyue is committed to helping international patients navigate this journey and access the resources they need to make informed healthcare decisions.