The Zang lab has made numerous important contributions to the fields of immune checkpoint and immunotherapy, such as the discovery of 3 (B7x, HHLA2, TMIGD2) out of 13 members of the B7 and CD28 families (major immune checkpoints), identification of the HHLA2-KIR3DL3 immunosuppressive pathway and the HHLA2-TMIGD2 immunostimulatory pathway.
Two novel immune checkpoint inhibitors from the Zang lab is currently in several phase II and phase I clinical trials in patients with advanced solid tumors and recurrent/refractory hematologic malignancies.
Check out their team page and vote for them! https://www.molecularcloud.org/researchawards2023/detail/xingxing-zang
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