Neutralization of SARS-CoV-2 spike pseudotyped virus by recombinant ACE2-Ig


Corresponding author: Shi Hu

Affiliations: Second Military Medical University

Publication date: this article was published online on April 24, 2020

DOI: http://doi.org/10.1038/s41467-020-16048-4

Highlights

The researchers generate a recombinant protein by connecting the extracellular domain of human ACE2 to the Fc region of the human immunoglobulin IgG1. A fusion protein containing an ACE2 mutant with low catalytic activity is also used in this study. The fusion proteins are then characterized. Both fusion proteins have a high binding affinity for the receptor-binding domains of SARS-CoV and SARS-CoV-2 and exhibit desirable pharmacological properties in mice. Moreover, they also demonstrated that the fusion proteins neutralize virus pseudotyped with SARS-CoV or SARS-CoV-2 spike proteins in vitro.

Nomination Reason

This work reveal that an ACE2-Ig exhibit cross-reactivity against coronaviruses, and have potential applications in the diagnosis, prophylaxis, and treatment of SARS-CoV-2.

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This article has been nominated for Distinguished Research Awards, you can visit the website below and vote for the nominated publications:

https://www.molecularcloud.org/awards-for-distinguished-research.html.






3 Reply

Have the author test it in vivo?


This work highlight the usage of ACE2 protein in COVID19, it is very useful!


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