CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats), a revolutionary gene-editing tool which has the ability to edit nearly any segment of DNA with more precise than any other DNA-editing tools. This DNA editing tool is highly used in the cancer research field in the recent years. There are a number of different cancer types with different mutation and few genetic mutations are common between many cancer types. These genetic mutations can either act as an oncogene or tumor suppressor leading to uncontrolled cell growth. With the CRISPR we can introduce specific site mutations, silence or overexpress genes of interest, or add large sequences to change the function of that gene and can use it to treat any cancer. Recent studies has shown various genes and its role in cancer metastasis, with this DNA editing tool we can precisely see the function of the gene by mutating and look at the cancer cell behavior.