Bovine Ultralong CDR3H Antibody Generation Service

Complementarity determining regions (CDRs) are the most important structure parts of an antibody that recognize antigens. The specificity of an antibody is mostly governed by its largest CDR, i.e. CDR H3. Compared with antibodies from other species, bovine antibodies are unusual in having exceptionally long CDR H3 loops; about 10% of bovine antibodies have ultralong CD3 H3 regions (35-60 AAs). Evidence has shown that these ultralong antibodies may be more effective in defense against disease than typical antibodies.

Alpha Lifetech Inc. is a recognized leader in the field of antibody discovery. We have developed proprietary procedures for antibody discovery. Our optimized library construction and screening processes with phage display technology guarantee successful isolation of high affinity antibodies in a short time. Alpha Lifetech Inc. has successfully produced multiple positive clones for a variety of antigens, ranging from large protein molecules (>400kD) to small haptens (small chemical molecules of ~200 dalton), many of the binders have sub-nanomolar affinities measured by ELISA.