A pneumonia outbreak associated with a new coronavirus of probable bat origin


Corresponding author: Zheng-Li Shi

Affiliations: CAS Key Laboratory of Special Pathogens, Wuhan Institute of Virology, Center for Biosafety Mega-Science, Chinese Academy of Sciences, Wuhan, China; Wuhan Jin Yin-Tan Hospital, Wuhan, China; University of Chinese Academy of Sciences, Beijing, China; Hubei Provincial Center for Disease Control and Prevention, Wuhan, China.

Publication date: this article was published on February 3, 2020. 

DOI: https://doi.org/10.1038/s41586-020-2012-7 

Highlights

In this article, researchers obtained full-length genome sequences from five patients at the early stage of the outbreak. The sequences are almost identical and share 79.6% sequence identity to SARS-CoV. Furthermore, they show that the 2019 novel coronavirus is 96% identical at the whole-genome level to a bat coronavirus. Pairwise protein sequence analysis of seven conserved non-structural proteins domains show that this virus belongs to the species of SARSr-CoV. Notably, they confirmed that 2019-nCoV uses the same cell entry receptor-angiotensin converting enzyme II (ACE2)-as SARS-CoV.

Nomination Reasons

The researchers reported the identification and characterization of the 2019 novel coronavirus shortly after the pandemic began. Notably, they confirmed that 2019 novel coronavirus uses the same cell entry receptor-angiotensin converting enzyme II (ACE2) as SARS-CoV.

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3 Reply

在严重的疫情发生之际,科学家们日以继夜地对本次疫情的研究有助于全人类早日战胜疫情提供了坚实地理论基础,感谢各位奋站在一线的科学家们,有你们,我们更有希望战胜疫情


This paper might be regarded as one of the biological milestone. For beingthe first journal published article to address the respiratory illness containing the SARS-Cov 2.


本文通过对患者的病原体进行测序,证实了病原体与蝙蝠冠状病毒具有96%的相似性,从而说明感染的病原体是一种新型冠状病毒。符合科赫法则,证据有力,结果可信。


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