Designing your gRNA sequences involves 4 steps:Determining the target gene locus.Finding suitable sequences for Cas9 targeting.Checking the potential for off-target binding.Selecting gRNAs sequences that lie within your preferred binding region.GenScript's gRNA database and online ...Learn More

A minimum of 3 gRNA sequences are recommended to ensure knock-out and experimental accuracy. Independently obtained knock-out mutants provide redundancy to safeguard against any hidden off-target effects. ...Learn More

There are many different types of gene editing, we can check the GenScript handbook for details. ...Learn More

Chromatin immunoprecipitation (ChIP) is a type of immunoprecipitation experimental technique used to investigate the interaction between proteins and DNA in the cell. It aims to determine whether specific proteins are associated with specific genomic regions, such as transcription ...Learn More

CAR T-cell therapy is a type of cancer therapy that uses a patient’s own modified white blood cells to kill cancer cells. T cells are changed in the laboratory. The gene for a special receptor called a chimeric antigen receptor (CAR) will insert into the T cells. Then millions ...Learn More