Dr. Haisheng Yu received his doctoral degree in 2016 from the University of Chinese Academy of Sciences. Since 2018, he has been working in the institute of Laboratory Animal Science, Chinese Academy of Medical Sciences (CAMS) & Peking Union Medical College (PUMC). Dr. Yu’s research focuses on the virus infection and immunity. The detailed research topics include: HIV&EBV pathogenesis in a humanized mice model with human immune system, Developing humanized mice model with human immune system and patient-derived tumors (hu-PDX) for evaluating immunotherapy of cancers, Human dendritic cells and its role in viral infection.
Research Area and Skills
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Virus Infection and Immunity 2
Papers related with humanized mice
Zhao J, Cheng L, Wang H, Yu H, Tu B, Fu Q, Li G, Wang Q, Sun Y, Zhang X, Liu Z, Chen W, Zhang L, Su L, Zhang Z. (2018). "Infection and depletion of CD4+ group-1 innate lymphoid cells by HIV-1 via type-I interferon pathway." PLoS Pathog 14(1): e1006819.
Cheng L, Yu H, Li G, Li F, Ma J, Li J, Chi L, Zhang L, Su L. (2017). "Type I interferons suppress viral replication but contribute to T cell depletion and dysfunction during chronic HIV-1 infection." JCI Insight 2(12).
Cheng L, Ma J, Li J, Li D, Li G, Li F, Zhang Q, Yu H, Yasui F, Ye C, Tsao LC, Hu Z, Su L, Zhang L. (2017). "Blocking type I interferon signaling enhances T cell recovery and reduces HIV-1 reservoirs." J Clin Invest 127(1): 269-279.
Li G, Cheng M, Nunoya J, Cheng L, Guo H, Yu H, Liu YJ, Su L, Zhang L. (2014). “Plasmacytoid dendritic cells suppress HIV-1 replication but contribute to HIV-1 induced immunopathogenesis in humanized mice.” PLoS Pathog 10(7): e1004291.
Papers related with Human dendritic cells
Yin X*, Yu H*, Jin X, Li J, Guo H, Shi Q, Yin Z, Xu Y, Wang X, Liu R, Wang S, Zhang L. (2017). "Human Blood CD1c+ Dendritic Cells Encompass CD5high and CD5low Subsets That Differ Significantly in Phenotype, Gene Expression, and Functions." J Immunol 198(4): 1553-1564. (*, Co-first author)
Ding J, Zhao J, Yang Z, Ma L, Mi Z, Wu Y, Guo J, Zhou J, Li X, Guo Y, Peng Z, Wei Tao, Yu H, Zhang L, Ge M, Cen S. (2017). "Microbial Natural Product Alternariol 5-O-Methyl Ether Inhibits HIV-1 Integration by Blocking Nuclear Import of the Pre-Integration Complex." Viruses 9(5): 105.
Li J, Du Q, Hu R, Wang Y, Yin X, Yu H, Du P, Plumas J, Chaperot L, Liu YJ, Zhang L. (2016). "Death receptor 6 is a novel plasmacytoid dendritic cell-specific receptor and modulates type I interferon production." Protein Cell 7(4): 291-294.