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Cyclization of peptides has been shown to be an important tool for structure-activity studies and drug development. The ring structure of cyclic peptides can be formed through four strategies, as shown in figure 1, including “head-to-tail cyclization” ”head-to-side chain ...Learn More


Peptide nucleic acids (PNAs) are synthetic nucleic acid analogs, which were first synthesized in 1991 by Peter E. Nielsen and colleagues. As shown in figure 1, unlike DNA and RNA, the phosphate sugar backbone of PNA is replaced by repeating N-(2-aminoethyl)-glycine units. ...Learn More


The generation of custom antibodies can be accomplished by using one of two primary approaches: full length protein and short peptides, but synthetic peptide antigens are often too small to generate significant immune responses on their own.To overcome the bottleneck, synthetic ...Learn More


Fluorescent techniques are widely used in biological research, which are related to their high sensitivity, selectivity, fast response time, flexibility and experimental simplicity. Fluorescent tags or probes are ideal for many imaging and diagnostic applications, also are be used ...Learn More


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    Beate Escher

    Helmholtz Centre for Environmental Research–UFZ

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    Dimitri Kullmann

    UCL Queen Squaree Institute of Neurology

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    Changhao Bi

    Tianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences

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