Ben Yen

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CRISPR / Cas9 0


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The COVID-19 epidemic is ignited by the global spreading of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) [1], which has been the center of scientific research for an effective treatment since the beginning of the outbreak. SARS-CoV-2 is a betacoronavirus, which ...Learn More

In a paper published yesterday (25 August 2020), the researchers at the University of Hong Kong identified the first reinfection case of SARS-CoV-2 virus, and proved the reinfection with whole genome sequencing approaches.The patient is a 33-year-old immunocompetent male who ...Learn More

Following my last post, I recently read a paper which also investigated the Spike Protein of SARS-CoV-2 virions, though focused on the stalk protein which connects S to the viral membrane. In this paper, the researcher took a further analysis into the flexibility of the spikes and ...Learn More

Recent Paper on Spike Proteins Located on Intact Virions of SARS-CoV-2 (Ke, Z., Oton, J., Qu, K. et al. Structures and distributions of SARS-CoV-2 spike proteins on intact virions. Nature (2020). SARS-CoV-2 is betacoronavirus, ...Learn More

Computational tools are widely used to boost the CRISPR-Cas design -- a brief introduction to the algorithms behind sgRNA designThe application of CRISPR-Cas as a genome editing tool utilizes the action of Cas9-sgRNA complex; the artificial single-guide RNA (sgRNA), a ...Learn More

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