Indolicidin

Description:

Indolicidin, a member of the cathelicidin protein family, shows potent antimicrobial activity in vitro against bacteria and fungi. It is also highly cytotoxic to T-line cells.

Sequence:

ILPWKWPWWPWRR-NH2

General

References

Comments (0)

Name	Indolicidin
Category	Antimicrobial and Related Peptides
One Letter Code	ILPWKWPWWPWRR-NH2
Three Letter Code	{Ile}{Leu}{Pro}{Trp}{Lys}{Trp}{Pro}{Trp}{Trp}{Pro}{Trp}{Arg}{Arg}-NH2
Molecular Weight	1906.300
Application	Antimicrobial & Antiviral Peptides

Ösapay, Klara, et al. "Formation and characterization of a single Trp-Trp cross-link in indolicidin that confers protease stability without altering antimicrobial activity." Journal of Biological Chemistry 275.16 (2000): 12017-12022.

Zeitler, Benjamin, et al. "De-novo design of antimicrobial peptides for plant protection." PLoS one 8.8 (2013): e71687.

Mattila, Juha-Pekka, Karen Sabatini, and Paavo KJ Kinnunen. "Oxidized phospholipids as potential molecular targets for antimicrobial peptides." Biochimica et Biophysica Acta (BBA)-Biomembranes 1778.10 (2008): 2041-2050.

Zhao, Hongxia, et al. "Comparison of the membrane association of two antimicrobial peptides, magainin 2 and indolicidin." Biophysical Journal 81.5 (2001): 2979-2991.