IGF-I Analog JB-1

Description:

The IGF-I peptide analog JB-1 is able to inhibit the autophosphorylation of the IGF-I receptor by IGF-I as well as the growth of several different cell types, including prostate carcinoma cells and SV40-transformed cells.

Sequence:

CYAAPLKPAKSC (Disulfide bridge: 1-12)

General

References

Comments (0)

Name	IGF-I Analog JB-1
Category	Growth Factors and Fragments
One Letter Code	CYAAPLKPAKSC (Disulfide bridge: 1-12)
Three Letter Code	{Cys}{Tyr}{Ala}{Ala}{Pro}{Leu}{Lys}{Pro}{Ala}{Lys}{Ser}{Cys} (Disulfide bridge: 1-12) (Disulfide bridge: 1-12)
Molecular Weight	1249.520
Application	Cancer ResearchDiabetesGrowth Factors

Martin-Montañez, Elisa, et al. "Involvement of IGF-II receptors in the antioxidant and neuroprotective effects of IGF-II on adult cortical neuronal cultures." Biochimica et Biophysica Acta (BBA)-Molecular Basis of Disease 1842.7 (2014): 1041-1051.

Escott, Gustavo Monteiro, et al. "Insulin and IGF-I actions on IGF-I receptor in seminiferous tubules from immature rats." Biochimica et Biophysica Acta (BBA)-Biomembranes 1838.5 (2014): 1332-1337.

Park, Seok Joo, et al. "Growth hormone-releaser diet attenuates cognitive dysfunction in klotho mutant mice via insulin-like growth factor-1 receptor activation in a genetic aging model." Endocrinology and Metabolism 29.3 (2014): 336-348.

Baldini, Sara, et al. "Enriched early life experiences reduce adult anxiety-like behavior in rats: a role for insulin-like growth factor 1." Journal of Neuroscience 33.28 (2013): 11715-11723.