GRPP (human)

Description:

GRPP (human) also known as glicentin-related polypeptide (human) is a synthetic analog of a cleavage product resulting from proglucagon processing in pancreatic α- and intestinal L-cells.

Sequence:

RSLQDTEEKSRSFSASQADPLSDPDQMNED

General

References

Comments (0)

Name	GRPP (human)
Category	Glucagons and Glucagon-Like Peptides (GLP-1 and GLP-2)
One Letter Code	RSLQDTEEKSRSFSASQADPLSDPDQMNED
Three Letter Code	{Arg}{Ser}{Leu}{Gln}{Asp}{Thr}{Glu}{Glu}{Lys}{Ser}{Arg}{Ser}{Phe}{Ser}{Ala}{Ser}{Gln}{Ala}{Asp}{Pro}{Leu}{Ser}{Asp}{Pro}{Asp}{Gln}{Met}{Asn}{Glu}{Asp}
Molecular Weight	3384.510
Application	Diabetes

Whiting, Lynda, et al. "Glicentin‐related pancreatic polypeptide inhibits glucose‐stimulated insulin secretion from the isolated pancreas of adult male rats." Physiological reports 3.12 (2015): e12638.

Holst, Jens Juul. "Enteroglucagon." Annual review of physiology 59.1 (1997): 257-271.

Rouillé, Yves, et al. "Role of the prohormone convertase PC2 in the processing of proglucagon to glucagon." FEBS letters 413.1 (1997): 119-123.