(Ser⁸)-GLP-1 (7-36) amide (human, bovine, guinea pig, mouse, rat)

Description:

The replacement of alanine by serine significantly improved the plasma stability of GLP-1 (7-36) amide against DPP IV without impairing its insulinotropic activity.

Sequence:

HSEGTFTSDVSSYLEGQAAKEFIAWLVKGR-NH₂

General

References

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Name	(Ser⁸)-GLP-1 (7-36) amide (human, bovine, guinea pig, mouse, rat)
Category	Glucagons and Glucagon-Like Peptides (GLP-1 and GLP-2)
One Letter Code	HSEGTFTSDVSSYLEGQAAKEFIAWLVKGR-NH₂
Three Letter Code	{His}{Ser}{Glu}{Gly}{Thr}{Phe}{Thr}{Ser}{Asp}{Val}{Ser}{Ser}{Tyr}{Leu}{Glu}{Gly}{Gln}{Ala}{Ala}{Lys}{Glu}{Phe}{Ile}{Ala}{Trp}{Leu}{Val}{Lys}{Gly}{Arg}-NH₂
Molecular Weight	3313.680
Application	Diabetes

Shigemori, Tomohiro, Kouichi Kuroda, and Mitsuyoshi Ueda. "Functional screening system for yeast-secreted peptides acting on G-protein coupled receptors." AMB Express 5.1 (2015): 1-7.

Maida, Adriano, et al. "Differential importance of glucose-dependent insulinotropic polypeptide vs glucagon-like peptide 1 receptor signaling for beta cell survival in mice." Gastroenterology 137.6 (2009): 2146-2157.

Kastin, Abba J., Victoria Akerstrom, and Weihong Pan. "Interactions of glucagon-like peptide-1 (GLP-1) with the blood-brain barrier." Journal of Molecular Neuroscience 18.1-2 (2002): 7-14.

Ritzel, U., et al. "A synthetic glucagon-like peptide-1 analog with improved plasma stability." Journal of endocrinology 159.1 (1998): 93-102.