Glucagon - Like Peptide 1, GLP - 1 amide (human)

Description:

In response to Glucose ingestion, proglucagon in the intestinal L cells is cleaved into GLP-1 (1-36). Prior to secretion into the circulation, GLP-1 (1-36) is further processed into amidated GLP-1 (7-36) and glycine-extended GLP-1 (7-37) . GLP-1 peptides is used to investigate restoration of pancreatic beta cell function. It is also produced in the central nervous system.

Sequence:

HDEFERHAEGTFTSDVSSYLEGQAAKEFIAWLVKGR-NH2

General

References

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Name	Glucagon - Like Peptide 1, GLP - 1 amide (human)
Category	Glucagons and Glucagon-Like Peptides (GLP-1 and GLP-2)
One Letter Code	HDEFERHAEGTFTSDVSSYLEGQAAKEFIAWLVKGR-NH2
Three Letter Code	{His}{Asp}{Glu}{Phe}{Glu}{Arg}{His}{Ala}{Glu}{Gly}{Thr}{Phe}{Thr}{Ser}{Asp}{Val}{Ser}{Ser}{Tyr}{Leu}{Glu}{Gly}{Gln}{Ala}{Ala}{Lys}{Glu}{Phe}{Ile}{Ala}{Trp}{Leu}{Val}{Lys}{Gly}{Arg}-NH2
Molecular Weight	4111.500
Application	Diabetes

Deacon, Carolyn F. "Circulation and degradation of GIP and GLP-1." Hormone and metabolic research 36.11/12 (2004): 761-765.

Williams, John A. "GLP-1." Pancreapedia: The Exocrine Pancreas Knowledge Base (2014).