(D-Arg¹,D-Phe⁵,D-Trp⁷·⁹,Leu¹¹)-Substance P

Description:

(D-Arg¹,D-Phe⁵,D-Trp⁷·⁹,Leu¹¹)-Substance P is a low potency ghrelin receptor antagonist and also is a full inverse agonist (EC₅₀ = 5.2 nM).

Sequence:

{D-Arg}PKPfQ{D-Trp}F{D-Trp}LL-NH₂

General

References

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Name	(D-Arg¹,D-Phe⁵,D-Trp⁷·⁹,Leu¹¹)-Substance P
Category	Ghrelin and Obestatin
One Letter Code	{D-Arg}PKPfQ{D-Trp}F{D-Trp}LL-NH₂
Three Letter Code	{D-Arg}{Pro}{Lys}{Pro}{Gln}{Gln}{D-Trp}{Phe}{D-Trp}{Leu}{Leu}-NH₂
Molecular Weight	1516.860
Application	Obesity Research

Bennett, Kirstie A., et al. "Growth hormone secretagogues and growth hormone releasing peptides act as orthosteric super-agonists but not allosteric regulators for activation of the G protein Gαo1 by the ghrelin receptor." Molecular pharmacology 76.4 (2009): 802-811.

Wu, Rongqian, et al. "Ghrelin attenuates sepsis-induced acute lung injury and mortality in rats." American journal of respiratory and critical care medicine 176.8 (2007): 805-813.

Asakawa, A., et al. "Antagonism of ghrelin receptor reduces food intake and body weight gain in mice." Gut 52.7 (2003): 947-952.