Magainin 2

Description:

Magainin II is a hemolytic and antibiotic peptide isolated from frog skin. Magainins are positively charged and amphiphatic. Magainin II is thought to preferentially bind to the anionic phospholipids abundant in bacterial membranes with the formation of dynamic peptide-lipid supramolecular pore and cell permeabilization. Binding to artificial neutral membranes has also been demonstrated.

Sequence:

GIGKFLHSAKKFGKAFVGEIMNS

General

References

Comments (0)

Name	Magainin 2
Category	Antimicrobial and Related Peptides
One Letter Code	GIGKFLHSAKKFGKAFVGEIMNS
Three Letter Code	{Gly}{Ile}{Gly}{Lys}{Phe}{Leu}{His}{Ser}{Ala}{Lys}{Lys}{Phe}{Gly}{Lys}{Ala}{Phe}{Val}{Gly}{Glu}{Ile}{Met}{Asn}{Ser}
Molecular Weight	2466.900
Application	Antimicrobial & Antiviral Peptides

Dosler, Sibel, and Elif Karaaslan. "Inhibition and destruction of Pseudomonas aeruginosa biofilms by antibiotics and antimicrobial peptides." Peptides 62 (2014): 32-37.

Zeitler, Benjamin, et al. "De-novo design of antimicrobial peptides for plant protection." PLoS one 8.8 (2013): e71687.

Nguyen, Khoi Tan, et al. "Orientation determination of protein helical secondary structures using linear and nonlinear vibrational spectroscopy." The Journal of Physical Chemistry B 113.36 (2009): 12169-12180.

Shi, Yixin, et al. "PhoP‐regulated Salmonella resistance to the antimicrobial peptides magainin 2 and polymyxin B." Molecular microbiology 53.1 (2004): 229-241.

Caputo, E. "Moharram R, and Martin BM." Methods for on-chip protein analysis. Anal Biochem 321 (2003): 116-124.