Galanin (1-13)-Pro-Pro-(Ala-Leu-)₂Ala amide

Description:

An antagonist of the galanin receptor.

Sequence:

GWTLNSAGYLLGPPPALALA-NH₂
  • General
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  • Name Galanin (1-13)-Pro-Pro-(Ala-Leu-)₂Ala amide
    Category Galanin and Related Peptides
    One Letter Code GWTLNSAGYLLGPPPALALA-NH₂
    Three Letter Code {Gly}{Trp}{Thr}{Leu}{Asn}{Ser}{Ala}{Gly}{Tyr}{Leu}{Leu}{Gly}{Pro}{Pro}{Pro}{Ala}{Leu}{Ala}{Leu}{Ala}-NH₂
    Molecular Weight 1981.330
    Application Alzheimer's DiseaseObesity Research
    Fitzgerald, Lawrence W., et al. "Pharmacological and biochemical characterization of a recombinant human galanin GALR1 receptor: agonist character of chimeric galanin peptides." Journal of Pharmacology and Experimental Therapeutics 287.2 (1998): 448-456.
    McDonald, Michael P., et al. "Coadministration of galanin antagonist M40 with a muscarinic M1 agonist improves delayed nonmatching to position choice accuracy in rats with cholinergic lesions." Journal of Neuroscience 18.13 (1998): 5078-5085.
    Crawley, Jacqueline N., John K. Robinson, and Tamas Bartfai. "Galanin receptor antagonists M40 and C7 block galanin-induced feeding." Brain research 600.2 (1993): 268-272.
    Leibowitz, Sarah F., and Taewan Kim. "Impact of a galanin antagonist on exogenous galanin and natural patterns of fat ingestion." Brain research 599.1 (1992): 148-152.
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