Cilengitide

Description:

A potential cancer drug.

Sequence:

c(RGDf(Me)V)
  • General
  • References
  • Comments (0)
  • Name Cilengitide
    Category Fibronectin Fragments, RGD Peptides
    One Letter Code c(RGDf(Me)V)
    Three Letter Code Cyclo(-Arg-Gly-Asp-D-Phe-N-Me-Val) 
    Molecular Weight 588.660
    Application Adhesion Molecules & Extracellular Matrix ProteinsCancer ResearchRegenerative Medicine
    Cheng, Ngan Ching, Nico van Zandwijk, and Glen Reid. "Cilengitide inhibits attachment and invasion of malignant pleural mesothelioma cells through antagonism of integrins αvβ3 and αvβ5." PLoS One 9.3 (2014).
    Mas-Moruno, Carlos, Florian Rechenmacher, and Horst Kessler. "Cilengitide: the first anti-angiogenic small molecule drug candidate. Design, synthesis and clinical evaluation." Anti-Cancer Agents in Medicinal Chemistry (Formerly Current Medicinal Chemistry-Anti-Cancer Agents) 10.10 (2010): 753-768.
    Dechantsreiter, Michael A., et al. "N-Methylated cyclic RGD peptides as highly active and selective αvβ3 integrin antagonists." Journal of medicinal chemistry 42.16 (1999): 3033-3040.
    #[first_name]
    #[create_date]
    #[comment]
    Reply(#[reply_num])
    #[like_num]
  • #[first_name]
    #[create_date]
    #[comment]
    Reply
    #[like_num]