RGD-targeted Proapoptotic Peptide

Description:

RGD-4C conjugated to an all-D proapoptotic peptide.

Sequence:

ACDCRGDCFCGGklaklakklaklak (Disulfide bridge: 2 - 10, 4 - 8)

General

References

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Name	RGD-targeted Proapoptotic Peptide
Category	Fibronectin Fragments, RGD Peptides
One Letter Code	ACDCRGDCFCGGklaklakklaklak (Disulfide bridge: 2 - 10, 4 - 8)
Three Letter Code	{Ala}{Cys}{Asp}{Cys}{Arg}{Gly}{Asp}{Cys}{Phe}{Cys}{Gly}{Gly}{D-Lys}{D-Leu}{D-Ala}{D-Lys}{D-Leu}{D-Ala}{D-Lys}{D-Lys}{D-Leu}{D-Ala}{D-Lys}{D-Leu}{D-Ala}{D-Lys} (Disulfide bridge: 2-10, 4-8) (Disulfide bridge: 2 - 10, 4 - 8)
Molecular Weight	2708.340
Application	Apoptosis & NecrosisCancer ResearchRegenerative Medicine

Smolarczyk, Ryszard, et al. "Antitumor effect of RGD-4C-GG-D (KLAKLAK) 2 peptide in mouse B16 (F10) melanoma model." Acta Biochimica Polonica 53.4 (2006): 801-805.

Curnis, Flavio, et al. "Coupling tumor necrosis factor-α with αV integrin ligands improves its antineoplastic activity." Cancer Research 64.2 (2004): 565-571.

Su, Zi-Fen, et al. "In vitro and in vivo evaluation of a technetium-99m-labeled cyclic RGD peptide as a specific marker of αvβ3 integrin for tumor imaging." Bioconjugate chemistry 13.3 (2002): 561-570.