RGD - 4C

Description:

This peptide, a double cyclic peptide, binds preferentially to integrins(αvβ3 and αvβ5) at sites of tumor angiogenesis and inflammed synovium in-vivo

Sequence:

ACDCRGDCFCG (Disulfide bridge: 2 - 10, 4 - 8)

General

References

Comments (0)

Name	RGD - 4C
Category	Fibronectin Fragments, RGD Peptides
One Letter Code	ACDCRGDCFCG (Disulfide bridge: 2 - 10, 4 - 8)
Three Letter Code	{Ala}{Cys}{Asp}{Cys}{Arg}{Gly}{Asp}{Cys}{Phe}{Cys}{Gly} (Disulfide bridge: 2-10, 4-8) (Disulfide bridge: 2 - 10, 4 - 8)
Molecular Weight	1145.290
Application	Adhesion Molecules & Extracellular Matrix Proteins, Cancer Research,Regenerative Medicine

Curnis, Flavio, et al. "Coupling tumor necrosis factor-α with αV integrin ligands improves its antineoplastic activity." Cancer Research 64.2 (2004): 565-571.

Kim, Jin-Wook, and Hyo-Suk Lee. "Tumor targeting by doxorubicin-RGD-4C peptide conjugate in an orthotopic mouse hepatoma model." International journal of molecular medicine 14.4 (2004): 529-564.

Su, Zi-Fen, et al. "In vitro and in vivo evaluation of a technetium-99m-labeled cyclic RGD peptide as a specific marker of αvβ3 integrin for tumor imaging." Bioconjugate chemistry 13.3 (2002): 561-570.