Exendin 4

Description:

Exendin-4, an agonist of glucagon-like peptide 1 (GLP-1) receptor, induces release of insulin after food intake.

Sequence:

HGEGTFTSDLSKQMEEEAVRLFIEWLKNGGPSSGAPPPS-NH2

General

References

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Name	Exendin 4
Category	Exendins and Fragments
One Letter Code	HGEGTFTSDLSKQMEEEAVRLFIEWLKNGGPSSGAPPPS-NH2
Three Letter Code	{His}{Gly}{Glu}{Gly}{Thr}{Phe}{Thr}{Ser}{Asp}{Leu}{Ser}{Lys}{Gln}{Met}{Glu}{Glu}{Glu}{Ala}{Val}{Arg}{Leu}{Phe}{Ile}{Glu}{Trp}{Leu}{Lys}{Asn}{Gly}{Gly}{Pro}{Ser}{Ser}{Gly}{Ala}{Pro}{Pro}{Pro}{Ser}-NH2
Molecular Weight	4186.600
Application	DiabetesParkinson's DiseaseVeterinary Medicine

Varin, E. M., et al. "Inhibition of the MAP3 kinase Tpl2 protects rodent and human β-cells from apoptosis and dysfunction induced by cytokines and enhances anti-inflammatory actions of exendin-4." Cell death & disease 7.1 (2016): e2065-e2065.

Rulifson, Ingrid C., et al. "Identification of human islet amyloid polypeptide as a BACE2 substrate." PloS one 11.2 (2016).

Jodal, Andreas, et al. "Evaluation of ¹¹¹In-Labelled Exendin-4 Derivatives Containing Different Meprin β-Specific Cleavable Linkers." PLoS One 10.4 (2015).