gp91 ds - tat

Description:

This peptide is composed of gp91phox sequence linked to the human immunodeficiency virus-tat peptide. The tat sequence facilitates the entry of this peptide into all cells. It is used as a peptide inhibitor for NADPH oxidase assembly.

Sequence:

YGRKKRRQRRRCSTRIRRQL-NH2

General

References

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Name	gp91 ds - tat
Category	Enzyme Substrates and Inhibitors
One Letter Code	YGRKKRRQRRRCSTRIRRQL-NH2
Three Letter Code	{Tyr}{Gly}{Arg}{Lys}{Lys}{Arg}{Arg}{Gln}{Arg}{Arg}{Arg}{Cys}{Ser}{Thr}{Arg}{Ile}{Arg}{Arg}{Gln}{Leu}-NH2
Molecular Weight	2673.200
Application

Park, Laibaik, et al. "NADPH oxidase-derived reactive oxygen species mediate the cerebrovascular dysfunction induced by the amyloid β peptide." Journal of Neuroscience 25.7 (2005): 1769-1777.

Park, Laibaik, et al. "Nox2-derived radicals contribute to neurovascular and behavioral dysfunction in mice overexpressing the amyloid precursor protein." Proceedings of the National Academy of Sciences 105.4 (2008): 1347-1352.