H-Trp-Phe-Tyr-Ser(PO₃H₂)-Pro-Arg-pNA

Description:

chromogenic substrate for Pin1

Sequence:

WFY{Ser(PO₃H₂)}PR-p-Nitroanilide

General

References

Comments (0)

Name	H-Trp-Phe-Tyr-Ser(PO₃H₂)-Pro-Arg-pNA
Category	Enzyme Substrates and Inhibitors
One Letter Code	WFY{Ser(PO₃H₂)}PR-p-Nitroanilide
Three Letter Code	{Trp}{Phe}{Tyr}{Ser(PO₃H₂)}{Pro}{Arg}-p-Nitroanilide
Molecular Weight	1055.050
Application

Wang, Jing-Zhang, et al. "Aluminum (III) interferes with the structure and the activity of the peptidyl-prolyl cis-trans isomerase (Pin1): A new mechanism contributing to the pathogenesis of Alzheimer's disease and cancers?." Journal of inorganic biochemistry 126 (2013): 111-117.

Urusova, Darya V., et al. "Epigallocatechin-gallate suppresses tumorigenesis by directly targeting Pin1." Cancer prevention research 4.9 (2011): 1366-1377.

Duncan, Kelly E., et al. "Discovery and characterization of a nonphosphorylated cyclic peptide inhibitor of the peptidylprolyl isomerase, Pin1." (2011).

Yaffe, Michael B., et al. "Sequence-specific and phosphorylation-dependent proline isomerization: a potential mitotic regulatory mechanism." Science 278.5345 (1997): 1957-1960.