Suc - LLVY - AMC, fluorogenic substrate

Description:

This 7-amino-4-methylcoumarin (AMC) labeled peptide is widely used as a fluorogenic substrate for 20S proteasome, calpains and other chymotrypsin-like proteases.

Sequence:

Succinylation-LLVY-AMC

General

References

Comments (0)

Name	Suc - LLVY - AMC, fluorogenic substrate
Category	Enzyme Substrates and Inhibitors
One Letter Code	Succinylation-LLVY-AMC
Three Letter Code	Succinylation-{Leu}{Leu}{Val}{Tyr}-AMC
Molecular Weight	763.900
Application

Zieba, Barbara A., et al. "The proteasome maturation protein POMP increases proteasome assembly and activity in psoriatic lesional skin." Journal of dermatological science 88.1 (2017): 10-19.

Petersen, Anne, and Madeleine Zetterberg. "The immunoproteasome in human lens epithelial cells during oxidative stress." Investigative ophthalmology & visual science 57.11 (2016): 5038-5045.

Dorneburg, Carmen, et al. "γ-secretase inhibitor I inhibits neuroblastoma cells, with NOTCH and the proteasome among its targets." Oncotarget 7.39 (2016): 62799.

Schrader, Jil, et al. "The inhibition mechanism of human 20S proteasomes enables next-generation inhibitor design." Science 353.6299 (2016): 594-598.

Baehr, Leslie M., et al. "Age-related deficits in skeletal muscle recovery following disuse are associated with neuromuscular junction instability and ER stress, not impaired protein synthesis." Aging (Albany NY) 8.1 (2016): 127.