LEAP - 1, Hepcidin (human)

Description:

Also known as hepcidin. LEAP-1 is a liver-specific peptide, but may be detected in the heart and brain at a lesser amount.

Sequence:

DTHFPICIFCCGCCHRSKCGMCCKT (Disulfide bridge: 7 - 23, 10 - 13, 11 - 19, 14 - 22)

General

References

Comments (0)

Name	LEAP - 1, Hepcidin (human)
Category	Antimicrobial and Related Peptides
One Letter Code	DTHFPICIFCCGCCHRSKCGMCCKT (Disulfide bridge: 7 - 23, 10 - 13, 11 - 19, 14 - 22)
Three Letter Code	{Asp}{Thr}{His}{Phe}{Pro}{Ile}{Cys}{Ile}{Phe}{Cys}{Cys}{Gly}{Cys}{Cys}{His}{Arg}{Ser}{Lys}{Cys}{Gly}{Met}{Cys}{Cys}{Lys}{Thr} (Disulfide bridges: 7-23, 10-13, 11-19, 14-22) (Disulfide bridge: 7 - 23, 10 - 13, 11 - 19, 14 - 22)
Molecular Weight	2789.500
Application

Krause, Alexander, et al. "Isolation and biochemical characterization of LEAP‐2, a novel blood peptide expressed in the liver." Protein Science 12.1 (2003): 143-152.

Klüver, E., et al. "Chemical synthesis of β‐defensins and LEAP‐1/hepcidin." The Journal of peptide research 59.6 (2002): 241-248.

Hunter, Howard N., et al. "The solution structure of human hepcidin, a peptide hormone with antimicrobial activity that is involved in iron uptake and hereditary hemochromatosis." Journal of Biological Chemistry 277.40 (2002): 37597-37603.