Mca-(endo-1a-Dap(Dnp))-TNF-α (-5 to +6) amide (human)

Description:

a fluorogenic (FRET) peptide substrate for tumor necrosis factor (TNF) converting enzyme

Sequence:

MCA-PLAQAV{Dap(Dnp)}RSSSR-NH₂

General

References

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Name	Mca-(endo-1a-Dap(Dnp))-TNF-α (-5 to +6) amide (human)
Category	Enzyme Substrates and Inhibitors
One Letter Code	MCA-PLAQAV{Dap(Dnp)}RSSSR-NH₂
Three Letter Code	MCA-{Pro}{Leu}{Ala}{Gln}{Ala}{Val}{Dap(Dnp)}{Arg}{Ser}{Ser}{Ser}{Arg}-NH₂
Molecular Weight	1638.720
Application	Alzheimer's DiseaseCancer ResearchInflammation Research

Folgueras, Alicia R., et al. "Collagenase-2 deficiency or inhibition impairs experimental autoimmune encephalomyelitis in mice." Journal of Biological Chemistry 283.14 (2008): 9465-9474.

Neumann, Ulf, et al. "Characterization of Mca-Lys-Pro-Leu-Gly-Leu-Dpa-Ala-Arg-NH2, a fluorogenic substrate with increased specificity constants for collagenases and tumor necrosis factor converting enzyme." Analytical biochemistry 328.2 (2004): 166-173.

Powers, Michael E., et al. "Synergistic action of Staphylococcus aureus α-toxin on platelets and myeloid lineage cells contributes to lethal sepsis." Cell host & microbe 17.6 (2015): 775-787.