Mca-Gly-Lys-Pro-Ile-Leu-Phe-Phe-Arg-Leu-Lys(Dnp)-D-Arg-NH₂

Description:

FRET substrate for cathepsin D and E.

Sequence:

MCA- GKPILFFRL{Lys(Dnp)}{D-Arg}-NH₂

General

References

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Name	Mca-Gly-Lys-Pro-Ile-Leu-Phe-Phe-Arg-Leu-Lys(Dnp)-D-Arg-NH₂
Category	Enzyme Substrates and Inhibitors
One Letter Code	MCA- GKPILFFRL{Lys(Dnp)}{D-Arg}-NH₂
Three Letter Code	MCA-{Gly}{Lys}{Pro}{Ile}{Leu}{Phe}{Phe}{Arg}{Leu}{Lys(Dnp)}{D-Arg}-NH₂
Molecular Weight	1756.040
Application	Cancer Research

Woischnik, Markus, et al. "Cathepsin H and napsin A are active in the alveoli and increased in alveolar proteinosis." European Respiratory Journal 31.6 (2008): 1197-1204.

Zaidi, Nousheen, et al. "A new approach for distinguishing cathepsin E and D activity in antigen‐processing organelles." The FEBS journal 274.12 (2007): 3138-3149.

Zaidi, Nousheen, et al. "A novel cell penetrating aspartic protease inhibitor blocks processing and presentation of tetanus toxoid more efficiently than pepstatin A." Biochemical and biophysical research communications 364.2 (2007): 243-249.

Burster, Timo, et al. "Design of protease-resistant myelin basic protein-derived peptides by cleavage site directed amino acid substitutions." Biochemical pharmacology 74.10 (2007): 1514-1523.