H-Phe-Leu-Glu-Glu-Leu-OH

Description:

substrate of vitamin K-dependent carboxylase.

Sequence:

FLEEL
  • General
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  • Name H-Phe-Leu-Glu-Glu-Leu-OH
    Category Enzyme Substrates and Inhibitors
    One Letter Code FLEEL
    Three Letter Code {Phe}{Leu}{Glu}{Glu}{Leu}
    Molecular Weight 649.740
    Application
    Azuma, Kotaro, et al. "Liver-specific γ-glutamyl carboxylase-deficient mice display bleeding diathesis and short life span." PloS one 9.2 (2014).
    Kinoshita, Hiroyuki, et al. "A functional single nucleotide polymorphism in the vitamin-K-dependent gamma-glutamyl carboxylase gene (Arg325Gln) is associated with bone mineral density in elderly Japanese women." Bone 40.2 (2007): 451-456.
    Tie, Jian-Ke, et al. "Determination of disulfide bond assignment of human vitamin K-dependent γ-glutamyl carboxylase by matrix-assisted laser desorption/ionization time-of-flight mass spectrometry." Journal of Biological Chemistry 278.46 (2003): 45468-45475.
    Presnell, Steven R., et al. "A novel fluorescence assay to study propeptide interaction with γ-glutamyl carboxylase." Biochemistry 40.39 (2001): 11723-11733.
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