Z-Arg-Leu-Arg-Gly-Gly-AMC

Description:

A fluorogenic substrate for the deubiquitinating enzyme isopeptidase T (IPaseT) and other ubiquitin C-terminal hydrolases (UCHs)

Sequence:

CBZ-RLRGG-AMC

General

References

Comments (0)

Name	Z-Arg-Leu-Arg-Gly-Gly-AMC
Category	Enzyme Substrates and Inhibitors
One Letter Code	CBZ-RLRGG-AMC
Three Letter Code	CBZ-{Arg}{Leu}{Arg}{Gly}{Gly}-AMC
Molecular Weight	848.960
Application

Daczkowski, Courtney M., et al. "Structurally guided removal of DeISGylase biochemical activity from papain-like protease originating from Middle East respiratory syndrome coronavirus." Journal of virology 91.23 (2017): e01067-17.

Lee, Hyun, et al. "Inhibitor recognition specificity of MERS-CoV papain-like protease may differ from that of SARS-CoV." ACS chemical biology 10.6 (2015): 1456-1465.

Báez-Santos, Yahira M., et al. "X-ray structural and biological evaluation of a series of potent and highly selective inhibitors of human coronavirus papain-like proteases." Journal of medicinal chemistry 57.6 (2014): 2393-2412.

Lee, Hyun, et al. "Synergistic Inhibitor Binding to the Papain‐Like Protease of Human SARS Coronavirus: Mechanistic and Inhibitor Design Implications." ChemMedChem 8.8 (2013): 1361-1372.