Z-Leu-Leu-Glu-AMC

Description:

Z-LLE-AMC is a fluorogenic substrate for measuring the peptidylglutamyl-peptide-hydrolyzing (PGPH) activity of the 20S proteasome.

Sequence:

CBZ-LLE-AMC

General

References

Comments (0)

Name	Z-Leu-Leu-Glu-AMC
Category	Enzyme Substrates and Inhibitors
One Letter Code	CBZ-LLE-AMC
Three Letter Code	CBZ-{Leu}{Leu}{Glu}-AMC
Molecular Weight	664.760
Application

Sosič, Izidor, et al. "Nonpeptidic Selective Inhibitors of the Chymotrypsin‐Like (β5 i) Subunit of the Immunoproteasome." Angewandte Chemie International Edition 55.19 (2016): 5745-5748.

Brehm, Anja, et al. "Additive loss-of-function proteasome subunit mutations in CANDLE/PRAAS patients promote type I IFN production." The Journal of clinical investigation 125.11 (2015): 4196-4211.

Mihoubi, Mohamed, et al. "Synthesis of C3/C1-Substituted Tetrahydroisoquinolines." Molecules 20.8 (2015): 14902-14914.

Scarbaci, Kety, et al. "Identification of a new series of amides as non-covalent proteasome inhibitors." European journal of medicinal chemistry 76 (2014): 1-9.