Boc-Arg-Val-Arg-Arg-AMC

Description:

The fluorogenic substrate Boc-RVRR-AMC is efficiently cleaved by furin.

Sequence:

Boc-RVRR-AMC

General

References

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Name	Boc-Arg-Val-Arg-Arg-AMC
Category	Enzyme Substrates and Inhibitors
One Letter Code	Boc-RVRR-AMC
Three Letter Code	Boc-{Arg}{Val}{Arg}{Arg}-AMC
Molecular Weight	843.010
Application

Waern, Ida, et al. "IL‐6 and IL‐17A degradation by mast cells is mediated by a serglycin: serine protease axis." Immunity, inflammation and disease 4.1 (2016): 70-79.

Kibirev, V. K., et al. "Synthesis, biological evaluation and docking of novel bisamidinohydrazones as non-peptide inhibitors of furin." The Ukrainian biochemical journal 87,№ 1 (2015): 55-63.

Liu, Yaling, et al. "Enzyme-controlled intracellular self-assembly of 18F nanoparticles for enhanced microPET imaging of tumor." Theranostics 5.10 (2015): 1058.

Dragulescu-Andrasi, Anca, et al. "Activatable oligomerizable imaging agents for photoacoustic imaging of furin-like activity in living subjects." Journal of the American Chemical Society 135.30 (2013): 11015-11022.

Cao, Chun-Yan, et al. "Controlled intracellular self-assembly of gadolinium nanoparticles as smart molecular MR contrast agents." Scientific reports 3 (2013): 1024.