Boc-Ile-Glu-Gly-Arg-AMC

Description:

A specific, highly fluorogenic substrate for clotting enzyme factor Xa

Sequence:

Boc-IEGR-AMC

General

References

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Name	Boc-Ile-Glu-Gly-Arg-AMC
Category	Enzyme Substrates and Inhibitors
One Letter Code	Boc-IEGR-AMC
Three Letter Code	Boc-{Ile}{Glu}{Gly}{Arg}-AMC
Molecular Weight	730.820
Application	Hematology

Kristensen, Line Hyltoft, et al. "Releasing the brakes in coagulation Factor IXa by co-operative maturation of the substrate-binding site." Biochemical Journal 473.15 (2016): 2395-2411.

Dumez, Marie-Eve, et al. "The proline-rich motif of the proDer p 3 allergen propeptide is crucial for protease-protease interaction." PloS one 8.9 (2013).

Komiyama, Tomoko, et al. "Inhibition of furin/proprotein convertase-catalyzed surface and intracellular processing by small molecules." Journal of Biological Chemistry 284.23 (2009): 15729-15738.

Dumez, Marie-Eve, et al. "Activation Mechanism of Recombinant Der p 3 Allergen Zymogen CONTRIBUTION OF CYSTEINE PROTEASE Der p 1 AND EFFECT OF PROPEPTIDE GLYCOSYLATION." Journal of Biological Chemistry 283.45 (2008): 30606-30617.

Perzborn, E., et al. "In vitro and in vivo studies of the novel antithrombotic agent BAY 59‐7939—an oral, direct Factor Xa inhibitor." Journal of Thrombosis and Haemostasis 3.3 (2005): 514-521.