Boc-Phe-Ser-Arg-AMC

Description:

The fluorogenic substrate Boc-FSR-AMC is preferentially hydrolyzed by coagulation factor XIa. Stock solutions of Boc-FSR-AMC are best prepared in DMSO.

Sequence:

Boc-FSR-AMC

General

References

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Name	Boc-Phe-Ser-Arg-AMC
Category	Enzyme Substrates and Inhibitors
One Letter Code	Boc-FSR-AMC
Three Letter Code	Boc-{Phe}{Ser}{Arg}-AMC
Molecular Weight	665.750
Application	Hematology

Middendorp, Simon J., et al. "Peptide macrocycle inhibitor of coagulation factor XII with subnanomolar affinity and high target selectivity." Journal of medicinal chemistry 60.3 (2017): 1151-1158.

Di Nardo, Anna, et al. "Improved clinical outcome and biomarkers in adults with papulopustular rosacea treated with doxycycline modified-release capsules in a randomized trial." Journal of the American Academy of Dermatology 74.6 (2016): 1086-1092.

Danby, S. G., et al. "A functional mechanistic study of the effect of emollients on the structure and function of the skin barrier." British Journal of Dermatology 175.5 (2016): 1011-1019.

Assumpcao, Teresa C., et al. "In vitro mode of action and anti-thrombotic activity of boophilin, a multifunctional Kunitz protease inhibitor from the midgut of a tick vector of babesiosis, Rhipicephalus microplus." PLoS neglected tropical diseases 10.1 (2016).

Valdes, James J., et al. "Tryptogalinin is a tick Kunitz serine protease inhibitor with a unique intrinsic disorder." PLoS One 8.5 (2013).

Baeriswyl, Vanessa, et al. "Development of a selective peptide macrocycle inhibitor of coagulation factor XII toward the generation of a safe antithrombotic therapy." Journal of medicinal chemistry 56.9 (2013): 3742-3746.