Ac-Calpastatin (184-210) (human)

Description:

A calpain inhibitor homologous to the minimal inhibitory domain I of human calpastatin

Sequence:

Ac-DPMSSTYIEELGKREVTIPPKYRELLA-NH₂

General

References

Comments (0)

Name	Ac-Calpastatin (184-210) (human)
Category	Enzyme Substrates and Inhibitors
One Letter Code	Ac-DPMSSTYIEELGKREVTIPPKYRELLA-NH₂
Three Letter Code	Acetylation-{Asp}{Pro}{Met}{Ser}{Ser}{Thr}{Tyr}{Ile}{Glu}{Glu}{Leu}{Gly}{Lys}{Arg}{Glu}{Val}{Thr}{Ile}{Pro}{Pro}{Lys}{Tyr}{Arg}{Glu}{Leu}{Leu}{Ala}-NH₂
Molecular Weight	3177.670
Application	Alzheimer's Disease

Demeure, Kevin, Valérie Gabelica, and Edwin Andre De Pauw. "New advances in the understanding of the in-source decay fragmentation of peptides in MALDI-TOF-MS." Journal of the American Society for Mass Spectrometry 21.11 (2010): 1906-1917.

Ivanova, Saka, et al. "Chapter nine lysosomes in apoptosis." Methods in enzymology 442 (2008): 183-199.

Cirman, Tina, et al. "Selective disruption of lysosomes in HeLa cells triggers apoptosis mediated by cleavage of Bid by multiple papain-like lysosomal cathepsins." Journal of Biological Chemistry 279.5 (2004): 3578-3587.

Yamazaki, Tsuneo, et al. "Specific increase in amyloid β-protein 42 secretion ratio by calpain inhibition." Biochemistry 36.27 (1997): 8377-8383.