H-D-Val-Leu-Lys-AMC

Description:

Highly specific fluorescent substrate for plasmin.

Sequence:

{D-Val}LK-AMC

General

References

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Name	H-D-Val-Leu-Lys-AMC
Category	Enzyme Substrates and Inhibitors
One Letter Code	{D-Val}LK-AMC
Three Letter Code	{D-Val}{Leu}{Lys}-AMC
Molecular Weight	515.650
Application	Hematology

Middendorp, Simon J., et al. "Peptide macrocycle inhibitor of coagulation factor XII with subnanomolar affinity and high target selectivity." Journal of medicinal chemistry 60.3 (2017): 1151-1158.

de Maat, Steven, et al. "Plasmin is a natural trigger for bradykinin production in patients with hereditary angioedema with factor XII mutations." Journal of Allergy and Clinical Immunology 138.5 (2016): 1414-1423.

Baeriswyl, Vanessa, et al. "Development of a selective peptide macrocycle inhibitor of coagulation factor XII toward the generation of a safe antithrombotic therapy." Journal of medicinal chemistry 56.9 (2013): 3742-3746.

Rijken, D. C., et al. "Development of a new test for the global fibrinolytic capacity in whole blood." Journal of Thrombosis and Haemostasis 6.1 (2008): 151-157.