[Met5] - Enkephalin

Description:

Opioid growth factor (OGF) therapy alone or in combination with standard chemotherapies results in enhanced inhibition of DNA synthesis and tumor growth.

Sequence:

YGGFM

General

References

Comments (0)

Name	[Met5] - Enkephalin
Category	Enkephalins and Proenkephalins
One Letter Code	YGGFM
Three Letter Code	{Tyr}{Gly}{Gly}{Phe}{Met}
Molecular Weight	573.800
Application	Cancer Research

Labuz, Dominika, et al. "Distinct roles of exogenous opioid agonists and endogenous opioid peptides in the peripheral control of neuropathy-triggered heat pain." Scientific reports 6 (2016): 32799.

Lowe, J. D., and C. P. Bailey. "Functional selectivity and time‐dependence of μ‐opioid receptor desensitization at nerve terminals in the mouse ventral tegmental area." British journal of pharmacology 172.2 (2015): 469-481.

Lowe, Janet D., et al. "Role of G protein–coupled receptor kinases 2 and 3 in μ-opioid receptor desensitization and internalization." Molecular pharmacology 88.2 (2015): 347-356.

Pravdivtsev, Andrey N., et al. "High resolution NMR study of T1 magnetic relaxation dispersion. IV. Proton relaxation in amino acids and Met-enkephalin pentapeptide." The Journal of chemical physics 141.15 (2014): 10B606_1.

Khalefa, Baled I., et al. "Peripheral antinociceptive efficacy and potency of a novel opioid compound 14-O-MeM6SU in comparison to known peptide and non-peptide opioid agonists in a rat model of inflammatory pain." European journal of pharmacology 713.1-3 (2013): 54-57.

Assis, María Amparo, et al. "Decrease of lymphoproliferative response by amphetamine is mediated by dopamine from the nucleus accumbens: influence on splenic met-enkephalin levels." Brain, behavior, and immunity 25.4 (2011): 647-657.

Medina‐Casanellas, Silvia, et al. "Transient isotachophoresis in on‐line solid phase extraction capillary electrophoresis time‐of‐flight‐mass spectrometry for peptide analysis in human plasma." Electrophoresis 32.13 (2011): 1750-1759.

Bailey, Christopher P., et al. "Involvement of PKCα and G‐protein‐coupled receptor kinase 2 in agonist‐selective desensitization of µ‐opioid receptors in mature brain neurons." British journal of pharmacology 158.1 (2009): 157-164.

Rapp, Erdmann, et al. "Atmospheric pressure free liquid infrared MALDI mass spectrometry: Toward a combined ESI/MALDI-liquid chromatography interface." Analytical chemistry 81.1 (2009): 443-452.

Nagy, Péter, Anthony J. Kettle, and Christine C. Winterbourn. "Superoxide-mediated formation of tyrosine hydroperoxides and methionine sulfoxide in peptides through radical addition and intramolecular oxygen transfer." Journal of Biological Chemistry 284.22 (2009): 14723-14733.

Dezfuli, Bahram S., et al. "Inflammatory response to Dentitruncus truttae (Acanthocephala) in the intestine of brown trout." Fish & shellfish immunology 24.6 (2008): 726-733.

Dezfuli, B. S., et al. "Selected pathological, immunohistochemical and ultrastructural changes associated with an infection by Diphyllobothrium dendriticum (Nitzsch, 1824)(Cestoda) plerocercoids in Coregonus lavaretus (L.)(Coregonidae)." Journal of fish diseases 30.8 (2007): 471-482.

Mozziconacci, Olivier, et al. "Reactions of Hydrogen Atoms with Met‐Enkephalin and Related Peptides." Chemistry–A European Journal 13.7 (2007): 2029-2033.

Zagon, Ian S., and Patricia J. McLaughlin. "Opioid growth factor and the treatment of human pancreatic cancer: a review." World Journal of Gastroenterology: WJG 20.9 (2014): 2218.