(D-Ala²)-Leu-Enkephalin-Arg

Description:

Dalargin (DALE) shows antioxidant, antiischemic, and wound-healing properties.

Sequence:

Y{D-Ala}GFLR
  • General
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  • Name (D-Ala²)-Leu-Enkephalin-Arg
    Category Enkephalins and Proenkephalins
    One Letter Code Y{D-Ala}GFLR
    Three Letter Code {Tyr}{D-Ala}{Gly}{Phe}{Leu}{Arg} 
    Molecular Weight 725.850
    Application
    Kreuter, Jörg, et al. "Apolipoprotein-mediated transport of nanoparticle-bound drugs across the blood-brain barrier." Journal of drug targeting 10.4 (2002): 317-325.
    Schroeder, Ulrike, Petra Sommerfeld, and Bernhard A. Sabel. "Efficacy of oral dalargin-loaded nanoparticle delivery across the blood–brain barrier." Peptides 19.4 (1998): 777-780.
    Schroeder, Ulrike, et al. "Nanoparticle technology for delivery of drugs across the blood–brain barrier." Journal of pharmaceutical sciences 87.11 (1998): 1305-1307.
    Chu, Ivan K., et al. "Formation of molecular radical cations of enkephalin derivatives via collision-induced dissociation of electrospray-generated copper (II) complex ions of amines and peptides." Journal of the American Society for Mass Spectrometry 12.10 (2001): 1114-1119.
    Schröder, Ulrike, and Bernhard A. Sabel. "Nanoparticles, a drug carrier system to pass the blood-brain barrier, permit central analgesic effects of iv dalargin injections." Brain research 710.1-2 (1996): 121-124.
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