(D-Ala²,D-Leu⁵)-Enkephalin

Description:

Dalargin (DALE) shows antioxidant, antiischemic, and wound-healing properties.

Sequence:

Y{D-Ala}GF{D-Leu}

General

References

Comments (0)

Name	(D-Ala²,D-Leu⁵)-Enkephalin
Category	Enkephalins and Proenkephalins
One Letter Code	Y{D-Ala}GF{D-Leu}
Three Letter Code	{Tyr}{D-Ala}{Gly}{Phe}{D-Leu}
Molecular Weight	569.660
Application	Opioid Research

Sreekumar, Parameswaran G., et al. "Antiapoptotic properties of α-crystallin–derived peptide chaperones and characterization of their uptake transporters in human RPE cells." Investigative ophthalmology & visual science 54.4 (2013): 2787-2798.

Vezzi, Vanessa, et al. "Ligands raise the constraint that limits constitutive activation in G protein-coupled opioid receptors." Journal of Biological Chemistry 288.33 (2013): 23964-23978.

Chothe, Paresh P., et al. "Transport of hepcidin, an iron-regulatory peptide hormone, into retinal pigment epithelial cells via oligopeptide transporters and its relevance to iron homeostasis." Biochemical and biophysical research communications 405.2 (2011): 244-249.

Ananth, Sudha, et al. "Functional identification of a novel transport system for endogenous and synthetic opioid peptides in the rabbit conjunctival epithelial cell line CJVE." Pharmaceutical research 26.5 (2009): 1226-1235.

Eisinger, Daniela A., and Hermann Ammer. "δ-Opioid receptors stimulate ERK1/2 activity in NG108-15 hybrid cells by integrin-mediated transactivation of TrkA receptors." FEBS letters 582.23-24 (2008): 3325-3329.

Lee, Hye J., and Gordon L. Amidon. "The effect of enzyme inhibitor and absorption site following [D‐ala2, D‐leu5] enkephalin oral administration in rats." Biopharmaceutics & drug disposition 23.4 (2002): 131-141.